Open AccessGlucocorticoid receptors in normal human lymphocytes and human leukemia and lymphoma cells
Author(s) -
Steiner Ann E.,
Wittliff James L.
Publication year - 1988
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860020109
Subject(s) - glucocorticoid receptor , glucocorticoid , leukemia , receptor , lymphoma , endocrine system , medicine , hormone , endocrinology , biology , immunology , cancer research
Glucocorticoids have been used widely in the treatment of leukemia; however, response has been variable. Glucocorticoid receptors have been implicated as the molecular basis of response to this hormonal therapy. Glucocorticoid receptor levels have been found to extend over a wide range in normal human lymphocytes, as well as in various leukemia and lymphoma cells. In several cases, correlations have been made between the concentration of glucocorticoid receptors and patient response to endocrine therapy. Other at tempts have been made to correlate glucocorticoid receptor levels with age, sex, immunological subtype of cell, and hematological classification of leukemia.