Open AccessImmunoperoxidase staining for calcitonin and calmodulin in the cystic fibrosis lung: A possible new therapeutic strategy in cystic fibrosis
Author(s) -
Wolf Paul,
Kilbourn J. P.
Publication year - 1987
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860010303
Subject(s) - pathology , cystic fibrosis , calcitonin , lung , medicine , staining , immunoperoxidase , fibrosis , autopsy , copd , pulmonary fibrosis , immunology , antibody , monoclonal antibody
The presence of calcitonin and calmodulin has been demonstrated by immunoperoxidase staining in formalin‐fixed, paraffinembedded sections of lung from autopsy tissues of patients who died as a result of cystic fibrosis. Calcitonin has been stained and quantitated in solitary endocrine cells, which are increased in number and staining intensity in the cystic fibrosis lung compared to chronic obstructive pulmonary disease (COPD) and normal lungs. Cal modulin was increased in the bronchiolar epithelium and alveolar pneumocytes in cystic fibrosis lung as compared to COPD and normal lungs. Because of our findings, we are proposing a possible new therapeutic regimen for treatment of the pulmonary infection utilizing diuretics and calcium channel blocking agents.