Open AccessHela marker chromosomes in human breast tumors: Proposal about the origin of the hela cell line
Author(s) -
Krizman David B.,
Carpenter Nancy J.,
Pathak Sen,
Olivé Matilde,
Cailleau Relda,
Hsu T. C.
Publication year - 1987
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860010116
Subject(s) - hela , human breast , pathology , carcinoma , breast carcinoma , biology , cervical carcinoma , adenocarcinoma , cell culture , cancer research , medicine , cervical cancer , breast cancer , cancer , genetics
Previous cytogenetic studies have shown that marker chromosomes thought to be unique to the human carcinoma cell line HeLa exist in some human breast tumors, but these studies have not found such markers in human cervical carcinoma lines. The present investigation presents cytogenetic data on 10 breast carcinoma and adenocarcinoma samples taken from fresh solid tumors, pleural effusions, and cell lines established from pleural aspirates. G‐banding analysis showed that 10 of the 19 breast tumor samples studied exhibited one or more HeLa markers. The data have led us to believe that HeLa marker chromosomes are characteristic for human breast adenocarcinomas and infiltrating ductal carcinomas and that the origin of the HeLa line could have been a breast tumor metastatic to the cervix.