Open AccessRelationship between levels of urinary type IV collagen and renal injuries in patients with IgA nephropathy
Author(s) -
Io Hiroaki,
Hamada Chieko,
Fukui Mitsumine,
Horikoshi Satoshi,
Tomino Yasuhiko
Publication year - 2004
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.10099
Subject(s) - nephropathy , medicine , renal injury , urinary system , proteinuria , renal biopsy , gastroenterology , christian ministry , mesangial proliferative glomerulonephritis , kidney , urology , endocrinology , philosophy , theology , diabetes mellitus
Because type IV collagen is synthesized by podocytes and mesangial cells, we investigated the relationship between levels of urinary type IV collagen (uIV) and renal injuries in patients with IgA nephropathy. uIV was measured by a highly sensitive one‐step sandwich enzyme immunoassay prior to renal biopsy. Patients with IgA nephropathy were classified into four grades (grade 1 = good prognosis, grade 2 = relatively good prognosis, grade 3 = relatively poor prognosis, and grade 4 = poor prognosis) by the prognostic criteria of the Ministry of Health, Labor, and Welfare of Japan. Levels of uIV in grade 4 were significantly higher than those in grades 1–3. These levels tended to increase gradually due to progression of renal injuries. The grades were further divided into two groups: group I (good or relatively good prognoses) and group II (relatively poor or poor prognoses). Patients with proteinuria of <1.0 g/day were defined as groups Ip and IIp. The levels of uIV in group II were significantly higher than those in group I, and those in group IIp were significantly higher than those in group Ip. It appears that the level of uIV can be a useful marker for detection of renal injuries in IgA nephropathy. J. Clin. Lab. Anal. 18:14–18, 2004. © 2004 Wiley‐Liss, Inc.