Open AccessTAP1 gene Acc I polymorphism is associated with atopic bronchial asthma
Author(s) -
Hang LiangWen,
Hsia TeChun,
Chen WenChi,
Chen HueyYi,
Tsai FuuJen
Publication year - 2003
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.10068
Subject(s) - asthma , immunology , gene polymorphism , pathogenesis , medicine , odds ratio , allergy , gene , genotype , biology , genetics
Asthma is a hyperresponsive airway disease that may involve inflammation responses. A transporter associated with the antigen processing 1 gene (TAP1) is involved in antigen processing, and is therefore considered to play a role in the pathogenesis of bronchial asthma. The aim of this study was to test whether the polymorphisms of the TAP1 gene are a genetic marker for susceptibility to bronchial asthma. A normal control group comprised of 43 healthy people, and 116 patients with allergic asthma were examined in this study. The polymorphism was detected by polymerase chain reaction (PCR)‐based restriction analysis. Associations between atopic bronchial asthma and TAP1 polymorphisms were evaluated. The results revealed no significant differences between normal individuals and asthmatics in regard to the TAP1 gene Dpn II polymorphism ( P =0.752). However, there was a significant difference between the control and asthma groups as regards the TAP1 gene Acc I polymorphism ( P =0.020). The odds ratio (OR) of GG homozygotes of the TAP1 Acc I polymorphism was 229.8 compared with the AA homozygote group. The results show that the Acc I polymorphism may be an indicator for atopic bronchial asthma. J. Clin. Lab. Anal. 17:57–60, 2003. © 2003 Wiley‐Liss, Inc.