Open AccessPortable electrochemical blood uric acid meter
Author(s) -
Kuo ChinSung,
Hwu ChiiMin,
Lin YuehHui,
Huang YaHsueh,
Kao WeiYi,
Weih MeiJy,
Hsiao LiChuan,
Kwok Ching Fai,
Ho LowTone
Publication year - 2002
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.10030
Subject(s) - venous blood , intraclass correlation , medicine , coefficient of variation , blood sampling , surgery , chromatography , reproducibility , chemistry
We describe a new portable uric acid (UA) meter, called the UASure ® (Apex Biotechnology Corp., Hsinchu, Taiwan). The UASure ® is an electrochemical blood UA meter designed for fast monitoring of UA concentrations in one drop of capillary blood using an electrochemical test strip. We compared the UASure ® with the standard method, the Hitachi 7600 modular system (Hitachi, Tokyo, Japan), in 146 volunteers (average age 62.5 ± 12.8 years). Of these, 65 were known hyperuricemic subjects, 17 of whom received medical therapy. The patients donated their capillary and venous blood samples in random order. Capillary blood and one drop of venous blood were tested immediately by the UASure ® . The venous blood in the test tube was sent to the central laboratory for serum UA measurement by the Hitachi 7600. The intra‐assay coefficients of variation (CVs) of the UASure ® were 4.79%, 5.77%, and 3.08% at UA levels of 5.8, 7.1, and 13.5 mg/dl, respectively. The UA concentrations tested by the UASure ® correlated well with those by the Hitachi 7600 ( r = 0.87 in venous sampling and r = 0.78 in capillary sampling, P < 0.001). The intraclass correlation was good for venous samples by the UASure ® ( r I = 0.84, 95% CI 0.82–0.90), somewhat below the meaningful criterion for capillary samples by the UASure ® ( r I = 0.77, 95% CI 0.69–0.83). UASure ® with venous sampling is interchangeable with the standard method for UA measurement. J. Clin. Lab. Anal. 16:109–114, 2002. © 2002 Wiley‐Liss, Inc.