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Copper porphyrin‐catalyzed C(sp 2 ) — O bond construction via coupling phenols with formamides
Author(s) -
Yang Shuang,
Chen XiaoYan,
Xiong MingFeng,
Zhang Hao,
Shi Lei,
Lin DongZi,
Liu HaiYang
Publication year - 2021
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.202100046
Subject(s) - chemistry , formamides , catalysis , formamide , porphyrin , copper , phenols , intermolecular force , kinetic isotope effect , medicinal chemistry , photochemistry , organic chemistry , molecule , deuterium , physics , quantum mechanics
Copper porphyrin‐catalyzed construction of C(sp 2 )—O bond via coupling formamides with phenols was achieved firstly. A broad range of substrates afforded various carbamates in moderate to good yields with good functional group tolerance at low catalyst loading. Intermolecular competing kinetic isotope effect experiment indicated that the generation of formamide radical is the rate‐determining step of current cross‐dehydrogenative coupling (CDC) reaction. The research extends the application of metalloporphyrin in CDC reaction.