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Efficient synthesis of some V‐shaped methylene‐bridged compounds via regioselective condensation
Author(s) -
Zonouzi Afsaneh,
Hosseinzadeh Fatemeh,
Dehdari Shahrzad,
Abbasi Alireza,
Ng Seik Weng
Publication year - 2021
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.202100033
Subject(s) - chemistry , regioselectivity , methylene , condensation , condensation reaction , computational chemistry , pyrimidine , reaction conditions , combinatorial chemistry , stereochemistry , organic chemistry , thermodynamics , catalysis , physics
A number of new stable methanobenzo[7,8][1,3] dioxocino[4,5‐ d ]pyrimidine‐1,3(2 H )‐dione derivatives ( 4a‐l ) were synthesized using a simple one‐pot procedure with considerable efficiency. Reaction parameters were further optimized in order to achieve a single‐product procedure. Plausible routes for reaction progress were investigated and it was proved that the reaction goes through regioselective condensation yielding an interesting V‐shaped structure. Spectral data of all products under study were used to elucidate the chemical structure and X‐ray structure analysis was performed to unambiguously prove the proposed structure for 4c .