Premium
A case study of the iodine‐mediated cyclization of C 2 ′‐ OH ‐ and C 2 ‐OH ‐chalcones toward the synthesis of flavones: Reinvestigation of the mechanisms
Author(s) -
Tsai Hsin Yen,
Huang YuTzu,
Kuo CingLing,
Kuo ChiaJou,
Hu Anren,
Chen JihJung,
Shih TzengeLien
Publication year - 2021
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.202000482
Subject(s) - chemistry , flavones , iodine , medicinal chemistry , stereochemistry , organic chemistry , chromatography
Synthesis of flavones from chalcones via the iodine‐mediated cyclization required at least one hydroxy group at their C 2 ′‐positions. On the contrary, the ring oxidative cyclization from C 2 ‐OH‐chalcones under the same condition was unusual and reported only once. We evaluated the aforementioned method and found different results. The mechanisms in detail were discussed.