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Synthesis of hydantoin alkynes through palladium‐catalyzed reaction, antibacterial evaluation, and molecular docking studies
Author(s) -
Keivanloo Ali,
Lashkari Saeed,
Sepehri Saghi,
Bakherad Mohammad,
Abbaspour Sima
Publication year - 2021
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.202000475
Subject(s) - chemistry , hydantoin , micrococcus luteus , docking (animal) , aryl , catalysis , palladium , imidazolidine , in silico , stereochemistry , antibacterial activity , combinatorial chemistry , organic chemistry , bacteria , biochemistry , escherichia coli , medicine , alkyl , genetics , nursing , biology , gene
Novel 3‐(3‐(aryl)prop‐2‐yn‐1‐yl)‐5,5‐diphenylimidazolidine‐2,4‐diones were synthesized through the reaction of 5,5‐diphenyl‐3‐(prop‐2‐yn‐1‐yl)imidazolidine‐2,4‐dione and aryl iodides in the presence of a palladium‐copper catalytic in CH 3 CN at room temperature. All prepared compounds were examined against the two bacterial strains, Micrococcus luteus and Pseudomonas aeruginosa and subjected by molecular docking studies. The in silico study carried out to predict the conformation of the examined compounds recommended that these compounds could bind noticeably to key the residues at the active site of dihydropteroate synthase. The interactive, biochemical, and in silico studies were in concordance with each other.