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Titanium complexes bearing 2, 6‐bis ( o ‐hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple‐negative breast‐cancer cells
Author(s) -
Chen INi,
Ganta Prasanna Kumar,
Chung ShouJie,
Chang YuLun,
Chang HengYi,
Ding Shangwu,
Chen HsuanYing,
Chiu ChienChih,
Wu KuoHui
Publication year - 2021
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.202000393
Subject(s) - chemistry , cytotoxicity , triple negative breast cancer , in vitro , alkoxide , titanium , pyridine , cancer cell , breast cancer , stereochemistry , cancer research , cancer , biochemistry , medicinal chemistry , organic chemistry , medicine , biology , catalysis
Three titanium (Ti) compounds bearing 2,6‐bis( o ‐hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple‐negative breast cancer (TNBC) MDA‐MB‐231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that ( H L Me Ti‐O) 4 (IC 50 = 0.91 μ M) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.