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The versatility of carbohydrates in antimicrobial applications
Author(s) -
Xu Yuan,
Liu XueWei
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.202000356
Subject(s) - chemistry , antimicrobial , context (archaeology) , trojan horse , antibiotic resistance , biochemical engineering , nanotechnology , computational biology , risk analysis (engineering) , antibiotics , biochemistry , business , computer security , organic chemistry , computer science , biology , engineering , paleontology , materials science
The worsening situation of global drug resistance is urgently demanding for novel antimicrobial agents. Considerable efforts have been concentrated on developing new antibacterial therapies with new mode of actions, exerting no selective pressure on bacterial mutation, and minimizing toxicity to host cells. In this context, active targeting can greatly contribute to selectivity between pathogens and mammalian cells in which carbohydrates, playing important roles in numerous biological processes, can be employed as targeting ligands or “trojan horse.” This short account has discussed the recent results of carbohydrate‐based antimicrobial agents developed by our group. Other excellent works by other scientists and possible directions in the future are also discussed.