Premium
One‐pot synthesis of 1, 4‐dihydropyridine derivatives using the Fe 2 ZnAl 2 O 7 catalyzed Hantzsch three‐component reaction
Author(s) -
Zargarzadeh Reza,
Akbari Dilmaghani Karim,
Nikoo Abbas
Publication year - 2021
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.202000322
Subject(s) - chemistry , catalysis , yield (engineering) , sorption , solvent , nuclear magnetic resonance spectroscopy , ethyl acetoacetate , scanning electron microscope , chemical engineering , nuclear chemistry , organic chemistry , materials science , physics , adsorption , quantum mechanics , engineering , metallurgy
A facile, low‐cost, and effective one‐pot method was developed for the synthesis of 1,4‐dihydropyridine derivatives with high yields through the three‐component reaction of ammonium acetate, ethyl acetoacetate, and aromatic aldehydes using Fe 2 ZnAl 2 O 7 as catalyst. The reaction was conducted at 70–80°C temperature under solvent free conditions. The developed method had some great advantages, including safe and clean reaction conditions, high to excellent product yields, short reaction time, and a novel and powerful heterogeneous catalyst. The developed heterogeneous solid catalyst had high efficiency and reusability in one‐pot multi‐component syntheses such that it was easily reused four to five times without significant loss in efficiency and product yield. The catalyst was characterized by scanning Electron Microscopy (SEM)/energy‐dispersive X‐ray spectroscopy (EDS) and X‐ray diffraction techniques. N2 sorption isotherms of the prepared nanocomposite exhibited surface area 2.1313E+01 m 2 /g and total pore volume of 3.0957E‐02 cm 3 /g. Substituted dihydropyridine derivatives were characterized and confirmed using 1 H NMR and 13 C NMR, and elemental spectral data.