Cytotoxic and chemotaxonomic study of isolated metabolites from  Centaurea aegyptiaca | Zendy

Mohamed Tarik A. | Zendy; Elshamy Abdelsamed I. | Zendy; AbdElGawad Ahmed M. | Zendy; Hussien Taha A. | Zendy; ElToumy Sayed A. | Zendy; Efferth Thomas | Zendy; Hegazy MohamedElamir F. | Zendy

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Cytotoxic and chemotaxonomic study of isolated metabolites from Centaurea aegyptiaca

Author(s) -

Mohamed Tarik A.,

Elshamy Abdelsamed I.,

AbdElGawad Ahmed M.,

Hussien Taha A.,

ElToumy Sayed A.,

Efferth Thomas,

Hegazy MohamedElamir F.

Publication year - 2021

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.202000156

Subject(s) - pinoresinol , chemistry , tyrosol , centaurea , isoflavonoid , botany , sesquiterpene , lignan , stereochemistry , traditional medicine , biochemistry , phenols , asteraceae , flavonoid , biology , medicine , antioxidant

The aerial parts of Centaureaa egyptiaca afforded 10 secondary metabolites including four sesquiterpene lactones; chlorohyssopifolin A (centaurepensin) ( 1 ), rediolpidetriol ( 2 ), linichlorinA ( 3 ), and sinaicin ( 4 ), one monoterpene; loliolid ( 5 ), one phenolic: tyrosol ( 6 ), three lignans; arctigenin ( 7 ), matairesinol ( 8 ), and pinoresinol ( 9 ), and one steroid; ergosta‐5,22‐dien‐3‐ol ( 10 ). The cluster analysis of 32 Centaurea species revealed that C. aegyptiaca is closely related to C. repens and C. solstitialise . The isolated compounds ( 1 – 10 ) were screened against CCRF‐CEM‐leukemia, MDA‐MB‐231‐pcDNA3 breast cancer, and HCT116 (p53 + / + ) colon carcinoma cell lines. Compounds 1 and 2 were the most potent compounds against both leukemia and breast carcinoma cell lines.

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