Premium
Cytotoxic and chemotaxonomic study of isolated metabolites from Centaurea aegyptiaca
Author(s) -
Mohamed Tarik A.,
Elshamy Abdelsamed I.,
AbdElGawad Ahmed M.,
Hussien Taha A.,
ElToumy Sayed A.,
Efferth Thomas,
Hegazy MohamedElamir F.
Publication year - 2021
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.202000156
Subject(s) - pinoresinol , chemistry , tyrosol , centaurea , isoflavonoid , botany , sesquiterpene , lignan , stereochemistry , traditional medicine , biochemistry , phenols , asteraceae , flavonoid , biology , medicine , antioxidant
The aerial parts of Centaureaa egyptiaca afforded 10 secondary metabolites including four sesquiterpene lactones; chlorohyssopifolin A (centaurepensin) ( 1 ), rediolpidetriol ( 2 ), linichlorinA ( 3 ), and sinaicin ( 4 ), one monoterpene; loliolid ( 5 ), one phenolic: tyrosol ( 6 ), three lignans; arctigenin ( 7 ), matairesinol ( 8 ), and pinoresinol ( 9 ), and one steroid; ergosta‐5,22‐dien‐3‐ol ( 10 ). The cluster analysis of 32 Centaurea species revealed that C. aegyptiaca is closely related to C. repens and C. solstitialise . The isolated compounds ( 1 – 10 ) were screened against CCRF‐CEM‐leukemia, MDA‐MB‐231‐pcDNA3 breast cancer, and HCT116 (p53 + / + ) colon carcinoma cell lines. Compounds 1 and 2 were the most potent compounds against both leukemia and breast carcinoma cell lines.