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Synthesis, characterization, computational simulation, biological and anticancer evaluation of Pd(II), Pt(II), Zn(II), Cd(II), and Hg(II) complexes with 2‐amino‐4‐phenyl‐5‐selenocyanatothiazol ligand
Author(s) -
AlJanabi Ahmed S. M.,
Zaky Rania,
Yousef Tarak A.,
Nomi Bashar S.,
Shaaban Saad
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201900454
Subject(s) - chemistry , hela , escherichia coli , cytotoxicity , antibacterial activity , amine gas treating , bacteria , ligand (biochemistry) , metal , nuclear chemistry , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , cell , in vitro , genetics , receptor , biology , gene
New Pd(II), Pt(II), Zn(II), Cd(II), and Hg(II) complexes were synthesized from the reaction of 4‐phenyl‐5‐selenocyanatothiazol‐2‐amine (PhSeCNH) with metal chlorides. The produced compounds were characterized by various spectroscopic techniques. The Material Studio program was used to propose the best fit atomic skeletons for the isolated solid compounds by applying density functional theory. Quantum chemical parameters were determined from such modeling. Also, the synthesized complexes were screened for their cytotoxicity in breast adenocarcinoma (MCF‐7) and human cervical (HeLa) cell lines. Furthermore, the bactericidal activity of the investigated compounds was also evaluated against Staphylococcus aureus as a Gram‐positive bacteria as well as Pseudomonas aeruginosa and Escherichia coli as Gram‐negative bacteria.