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Synthesis, antimicrobial and antioxidant activity of bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl) methane
Author(s) -
Nagalakshmamma Vadabingi,
Varalakshmi Mavallur,
Umapriya Kollu,
Venkataswamy Mallepogu,
Venkataramaiah Chintha,
Thyaga Raju Kedam,
Chalapathi Ponne Venkata,
NagaRaju Chamarthi
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201900434
Subject(s) - chemistry , sulfonamide , antimicrobial , antioxidant , sulfonyl , methane , organic chemistry , carbamate , carbon 13 nmr , elemental analysis , medicinal chemistry , nuclear chemistry , alkyl
A series of new bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl)methane 3 ( a–d )/ 5 ( a–f ) were synthesized from bis‐(4‐aminophenyl)methane ( 1 ) using various pharmacologically active sulfonyl chlorides 2 ( a–d ) and carbonochloridates 4 ( a–f ) in high yields. The structures of all the newly synthesized compounds were characterized by the Infrared spectroscopy, NMR ( 1 H and 13 C), mass, and elemental analyses. Further, all the synthesized compounds were tested for the antioxidant activity by using 2, 2‐diphenyl‐1‐picrylhydrazyl, NO, and H 2 O 2 scavenging methods and antimicrobial activity. Most of the compounds exhibited good antioxidant and antimicrobial activities.