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Iodine‐catalyzed ultrasound‐assisted construction of pyridines and their glutamine synthetase molecular docking
Author(s) -
Pagadala Ramakanth,
Kasi Venkatesan,
Perugu Shyam
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201900389
Subject(s) - chemistry , iodine , catalysis , pyridine , combinatorial chemistry , ultrasound , docking (animal) , organic chemistry , medicine , physics , nursing , acoustics
Iodine‐promoted facile protocol is designed for the production of pyridines at room temperature under ultrasound irradiation. Eleven pyridine derivatives in excellent yields (91–97%) are synthesized with 2 hr reaction time. Additional advantage of the proposed ultrasound‐assisted eco‐friendly, cost‐effective protocol is easy separation of product, and our in silico studies show good binding affinity toward binding and made strong hydrogen interactions.