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Template‐engineered metal macrocyclic complexes: Synthesis and biological activity
Author(s) -
Sangwan Vikas,
Singh Dharam Pal
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201900290
Subject(s) - chemistry , macrocyclic ligand , ligand (biochemistry) , electron paramagnetic resonance , metal ions in aqueous solution , metal , divalent , pyrimidine , protonation , crystallography , stereochemistry , titration , inorganic chemistry , ion , organic chemistry , nuclear magnetic resonance , biochemistry , physics , receptor
Three new azamacrocylic complexes of divalent transition‐metal ions were synthesized by taking Co(II), Ni(II), and Cu(II) metal ions as templates. The macrocyclic ligand (1 2 Z ,5 2 Z ,5 4 E )‐1 1 ,1 2 ,1 3 ,1 4 ,1 5 ,1 6 ,5 1 ,5 2 ,5 3 ,5 4 ,5 5 ,5 6 ‐dodecahydro‐2,4,6,8‐tetraaza‐1 (2,4),5(4,2)‐pyrimidine‐3,7(1,2)‐dibenzenacyclooctaphane‐1 6 ,5 6 ‐dione was derived from o ‐phenylenediamine (OPD) and 2‐thiobarbituric acid (TBA). All the complexes were fully characterized through spectroscopic techniques and elemental analyses. The structures of the macrocyclic complexes were determined by IR, UV–vis, ESI‐MS, TGA, molar conductance, magnetic moment, and electron spin resonance data. On the basis of the above studies, the complexes may be formulated as [MLX 2 ], in which L is a macrocyclic ligand and X = CH 3 COO − . All the macrocyclic complexes were biologically screened to evaluate their antimicrobial efficacy. DNA binding study of two representative complexes was performed by UV–vis titrations.