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Retracted: A new mixed‐ligand coordination polymer based on V‐shape carboxylate and pyridinyl co‐linkers: Crystal structure, molecular docking, and antibladder cancer activity evolution
Author(s) -
Chen Si,
Liu WeiJuan,
Lin MingEn,
He XueJun,
Hong YingKai
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201900279
Subject(s) - chemistry , carboxylate , ligand (biochemistry) , coordination polymer , crystal structure , crystallography , stereochemistry , single crystal , receptor , biochemistry
Abstract By applying the mixed‐ligand approach, a new Cu(II)‐containing coordination polymer [Cu 4 (L) 4 (4,4′‐bpy)(H 2 O) 2 ]·3H 2 O ( 1 ) was successfully prepared through hydrothermal method using linear 4,4′‐bipyridine (4,4′‐bpy) and the V‐shape carboxylate ligand 4,4′‐(phenylazanediyl)dibenzoic acid (H 2 L). The as‐prepared complex 1 was determined by single‐crystal X‐ray crystallography and elemental analysis. Furthermore, we use the grinding method to prepare the samples of complex 1 in the nanoscale. In this research, the CCK‐8 was performed first to detect the inhibitory activity of complex 1 on J82 bladder cancer cell viability. The apoptotic effect of complex 1 on J82 cancer cells was evaluated by Annexin V‐FITC/PI staining. The reactive oxygen species (ROS) was also detected by detection kit in this study after complex 1 treatment. Beyond the experimental results, the molecular docking technique has been used to probe the anticancer activity that originated at the molecular level.