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Neuroprotective activity of different monosaccharide‐modified gastrodin analogs
Author(s) -
Xu KunLun,
Yu Lan
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201900223
Subject(s) - gastrodin , neuroprotection , chemistry , nitric oxide , nitric oxide synthase , monosaccharide , pharmacology , glycoside , biochemistry , stereochemistry , organic chemistry , chromatography , medicine
Gastrodin is a very important and well‐known bioactive glycoside compound in Chinese medicine. It is also known as a drug with neuroprotective function. Here, a practical diversified synthesis of a series of gastrodin analogs was reported, which involved four‐step procedures consisting of bromination, oxidation, etherification, and reduction. Various gastrodin analogs were obtained in good yields. The compound 4c in this study has a good neuroprotective function: it can significantly downregulate tumor necrosis factor‐α and inducible nitric oxide synthase protein levels. The results of this study can provide a research basis for the development of neuroprotective drugs.