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Green, rapid, and highly efficient syntheses of α , α′ ‐bis[(aryl or allyl)idene]cycloalkanones and 2‐[(aryl or allyl)idene]‐1‐indanones as potentially biologic compounds via solvent‐free microwave‐assisted Claisen–Schmidt condensation catalyzed by MoCl 5
Author(s) -
Bakhshi Reza,
Zeynizadeh Behzad,
Mousavi Hossein
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201900081
Subject(s) - chemistry , aryl , catalysis , microwave irradiation , solvent , combinatorial chemistry , organic chemistry , alkyl
A new, green, and highly efficient protocol for the expeditious preparation of some α , α′ ‐bis[(aryl or allyl)idene]cycloalkanones and 2‐[(aryl or allyl)idene]‐1‐indanones via a simple microwave‐assisted Claisen–Schmidt condensation reaction catalyzed by MoCl 5 was successfully developed. Outstanding features of the current methodology include the use of solvent‐free conditions, simple operation, use of a very inexpensive and available catalyst, low catalyst loading, short reaction times, high yields of the pure products, no harmful by‐products, easy workup, and also the applicability of microwave irradiation as a clean source of energy. Furthermore, a gram‐scale reaction was successfully conducted, proving the scalability of this current Claisen–Schmidt condensation reaction.