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Potentiometric, spectral characterization, and antioxidant activity studies of ternary complexes involving Cu(II) and carbamoylcholine chloride drug with amino acids
Author(s) -
AlOnazi Wedad A.,
AlMohaimeed Amal M.,
Almarhoon Zainab M.,
AlFarraj Eida S.,
Alothman Asma A.
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201900062
Subject(s) - chemistry , potentiometric titration , copper , ternary operation , electron paramagnetic resonance , stability constants of complexes , crystallography , imidazole , inorganic chemistry , nuclear chemistry , stereochemistry , organic chemistry , aqueous solution , nuclear magnetic resonance , ion , computer science , programming language , physics
A potentiometric method was used to determine the stability constants for the various complexes of copper(II) with carbamoylcholine chloride (C) drug as a ligand in the presence of some biorelevant amino acid constituents like glycine (Gly), alanine (Ala), valine (Val), proline (Pro), β‐phenylalanine (Phe), S‐methylcysteine (Met), threonine (Thr), ornithine (Orn), lysine (Lys), histidine (Hisd), histamine (Hist), and imidazole (Imz) as ligands (L). Stability constants of complexes were determined at 25°C and I = 0.10 mol/L NaNO 3 . The relative stability of each ternary complex was compared with that of the corresponding binary complexes in terms of Δlog K and % R.S. values. Cu(II) complexes of drug C were synthesized in 1:1 and 1:1:1 M ratios of copper to drug [Cu(C)(NO 3 ) 2 ] (1) and copper to drug to glycine[Cu(C)(Gly)(NO 3 )].NO 3 (2), respectively. Glycine ternary complex with drug and copper [Cu(C)(Gly)(NO 3 )].NO 3 was considered as representative amino acid. The complexes 1 and 2 were isolated and characterized using various physicochemical and spectral techniques. Both complexes 1 and 2 were found to have magnetic moments corresponding to one unpaired electron. The possible square planar and square‐pyramidal geometries of the copper (II) complexes were assigned on the basis of electron paramagnetic resonance (EPR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), X‐ray powder diffraction (XRPD), ultraviolet–visible (UV–Vis) and infrared (IR) spectral studies, and the discrete Fourier transform method from DMOL3 calculations. Antioxidant activities of all the synthesized compounds were also investigated.