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One‐pot synthesis of highly functionalized benzo [1,3] thiazine from isocyanides, aniline, and heterocumulene via Cu‐catalyzed intramolecular C‐H activation reactions
Author(s) -
Dastjerdi Hossein F.,
Nematpour Manijeh,
Rezaee Elham,
Jahani Mehdi,
Tabatabai Sayyed A.
Publication year - 2019
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800493
Subject(s) - chemistry , aniline , thiazine , catalysis , acetonitrile , yield (engineering) , intramolecular force , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , materials science , metallurgy
Abstract A one‐pot synthesis of functionalized benzo thiazine derivatives via a Cu‐catalyzed, multicomponent reaction of isocyanides, aniline, and heterocumulenes in acetonitrile at room temperature was developed. Transition metal‐catalyzed activation of C‐H bonds under mild copper‐catalytic reaction conditions, using simple and available starting materials, also obtaining a pure product with high yield without applying column chromatography are the major advantages of the applied method among the other ones used for this purpose. The structures are confirmed spectroscopically ( 1 H‐ and 13 C‐NMR, IR, and EI‐MS) and through elemental analyses.