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Synthesis, spectral characterization, and biological evaluation of imidazole‐substituted pyridine‐2‐amine and benzo‐substituted imidazole‐2‐amine
Author(s) -
Mahaboob Basha Shaik,
Varalakshmi Mavallur,
Thaslim Basha Shaik,
Venkataramaiah Chintha,
Syed Shafi Suban,
Naga Raju Chamarthi,
Rajendra Wudayagiri
Publication year - 2019
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800461
Subject(s) - chemistry , imidazole , amine gas treating , antimicrobial , pyridine , isothiocyanate , isopropyl , organic chemistry , aryl , isopropyl alcohol , antioxidant , benzimidazole , alkyl , combinatorial chemistry , medicinal chemistry
A series of new imidazole‐substituted pyridine‐2‐amine and benzo‐substituted imidazol‐2‐amine 3 – 12 were synthesized by treating various amines 1(a – d) with alkyl/aryl isothiocyanate 2(a‐c) at 60–90°C in isopropyl alcohol without using any catalyst with high yields. The structures of all the newly synthesized compounds were characterized using IR, NMR ( 1 H, 13 C), mass, and elemental analyses. All the newly synthesized compounds were screened for their in vitro antioxidant and antimicrobial activities to understand their biological potency. All the title compounds exhibited good antioxidant and antimicrobial activities in vitro when compared to the standard drugs.