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Green synthesis of bis‐coumarin derivatives using Fe(SD) 3 as a catalyst and investigation of their biological activities
Author(s) -
Mahmoodi Nosrat O.,
Jalalifard Zeinab,
Fathanbari Ghanbari Pirbasti
Publication year - 2020
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800444
Subject(s) - chemistry , micrococcus luteus , catalysis , antibacterial activity , cefotaxime , staphylococcus aureus , escherichia coli , coumarin , yield (engineering) , pseudomonas aeruginosa , bacteria , nuclear chemistry , organic chemistry , environmentally friendly , biochemistry , antibiotics , genetics , materials science , biology , metallurgy , gene , ecology
A convenient, practical, green, and environmentally friendly method was developed for the synthesis of biscoumarins and corresponding tetrakis products from the reaction of 4‐hydroxycoumarin and various aldehydes. The bis‐coumarins were synthesized in high yield under mild reaction conditions. Products were obtained in the presence of in situ prepared Fe(SD) 3 [Iron(III) dodecyl sulfate] as a combined Lewis acid–surfactant catalyst (LASC) in water in short reaction times. Also, the antibacterial activity of compounds was screened against Pseudomonas aeruginosa and Escherichia coli as Gram‐negative bacteria and Micrococcus luteus and Staphylococcus aureus as Gram‐positive bacterial strains. Products 3g , 3k–l were most active than cefotaxime against E. coli and also compounds 3c and 3g were most active than cefotaxime against S. aureus .