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Synthesis and evaluation of pyrazole‐incorporated monocarbonyl curcumin analogues as antiproliferative and antioxidant agents
Author(s) -
Nagargoje Amol A.,
Akolkar Satish V.,
Siddiqui Madiha M.,
Bagade Aditi V.,
Kodam Kisan M.,
Sangshetti Jaiprakash N.,
Damale Manoj G.,
Shingate Bapurao B.
Publication year - 2019
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800405
Subject(s) - chemistry , curcumin , antioxidant , pyrazole , ascorbic acid , in vitro , combinatorial chemistry , stereochemistry , docking (animal) , drug , organic chemistry , biochemistry , pharmacology , food science , medicine , nursing
A series of pyrazole‐incorporated monocarbonyl analogues of curcumin were synthesized via Clasien–Schimidt‐type condensation and subsequently screened for in vitro antiproliferative and antioxidant activity. The analogues 4c, 5d, 5e, 5g, 6e, and 6f showed potential activity against the MDA‐MB‐231 cell line. The synthesized analogues were also screened for their antioxidant activity. Compounds 5a , 5e , 6d, and 6f exhibit comparable radical scavenging activity with respect to the standard drug ascorbic acid. Furthermore, a molecular docking study has been conducted for 5d and 5g and suggests that these compounds have a potential to become lead molecules in drug discovery and process.