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Application of Cu(Hdmg) 2 as a simple and cost‐effective catalyst for the convenient one‐pot reductive acetylation of aromatic nitro compounds
Author(s) -
Zeynizadeh Behzad,
Mousavi Hossein,
Zarrin Saviz
Publication year - 2019
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800325
Subject(s) - chemistry , sodium borohydride , nitro , acetamide , acetylation , catalysis , borane , copper , organic chemistry , reducing agent , combinatorial chemistry , sodium acetate , medicinal chemistry , biochemistry , alkyl , gene
In this article, we have developed a novel and simple one‐pot reductive acetylation of aromatic nitro compounds with sodium borohydride (NaBH 4 ) in ethyl acetate (EtOAc) under reflux conditions in the presence of the bis(dimethylglyoximato)copper(II) complex [Cu(Hdmg) 2 ] as an efficient and cost‐effective copper‐containing catalyst. Notably, using the above‐mentioned one‐pot reaction, the corresponding acetamide derivatives were obtained in high to excellent yields.