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Surface modification by deposition of IPA plasma and gellan gum/chitosan hybrid hydrogel onto thermoplastic polyurethane for controlled release of N‐acetylcysteine
Author(s) -
Pan JiunnAn,
Liu HsuanLiang,
Ting WeiTing,
Hsu HongKai,
Chen KoShao
Publication year - 2019
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800297
Subject(s) - gellan gum , chemistry , contact angle , swelling , chitosan , chemical engineering , fourier transform infrared spectroscopy , polyurethane , scanning electron microscope , surface modification , polyelectrolyte , wetting , polyvinyl alcohol , thermoplastic polyurethane , polymer chemistry , nuclear chemistry , polymer , composite material , materials science , elastomer , organic chemistry , food science , engineering
A thin film system composed of gellan gum and chitosan was fabricated through a combination of polyelectrolyte blend and hybrid hydrogel gelation for controlled release of drug. In this study, precursor isopropyl alcohol (IPA) was used to plasma deposit on the surface of thermoplastic polyurethane (TPU) to form a hydrophilic film. The features of the thin film were evaluated using water contact angle (WCA) measurement, scanning electron microscopy (SEM), Fourier transform infra‐red (FTIR), UV/Vis spectroscopy, and studies of controlled release of drugs. The hybrid hydrogel, pH‐sensitive, was tested at pH values of 1.2 and 7.4 of buffer solution and at a temperature of 37°C to observe its swelling ratio and drug delivery properties with N‐acetylcysteine as a drug material for controlled release. Furthermore, at pH 7.4, the hybrid hydrogel has an outstanding release ratio of up to about 90% absorption amounts of N‐acetylcysteine after 8 hr. The mechanism of drug release from thin film devices ( n = 0.684) is anomalous (non‐Fickian) transport, the value of n lies between 0.43 and 0.85.