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KF/clinoptilolite nanoparticles as a novel catalyst for the green synthesis of chromens using three component reactions of 4‐hydroxycoumarins: Study of antioxidant activity
Author(s) -
Sharifi Samanehsadat,
Maghsoudlou Malek Taher,
Hazeri Nourallah,
RostamiCharati Faramarz
Publication year - 2019
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800282
Subject(s) - chemistry , clinoptilolite , catalysis , dpph , ferric , yield (engineering) , antioxidant , green chemistry , solvent , organic chemistry , combinatorial chemistry , reaction mechanism , zeolite , materials science , metallurgy
In this research, the green synthesis of chromen derivatives in good yields is described via three‐component reactions of 4‐hydroxycumarine, aldehydes or ketones, and methyl ketones in the presence of KF/clinoptilolite nanoparticles (KF/CP‐NPs) under solvent‐free conditions at 50°C in low time. The present methodology suggests some advantages such as low reaction time, easy and simple procedure, green method, inexpensive catalyst, high yield of product, and existence of different substrates for performing these reactions. In addition, it should be mentioned that antioxidant activity was studied for some prepared compounds, such as 4a–4d, by DPPH radical trapping and reducing potential tests of ferric ion and then comparing results with TBHQ and BHT as synthetic antioxidants. In this study, compounds 4c was shown to have moderate DPPH radical trapping, and compounds 4b and 4d displayed good reducing power of ferric ion.