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Biohybrid fluorescent nanodiamonds as dual‐contrast markers for light and electron microscopies
Author(s) -
Sotoma Shingo,
Hsieh FengJen,
Chang HuanCheng
Publication year - 2018
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800157
Subject(s) - cathodoluminescence , nanotechnology , surface modification , fluorescence , chemistry , nanomaterials , nanoparticle , luminescence , materials science , optics , optoelectronics , physics
Cathodoluminescence (CL) and correlative light‐electron microscopy (CLEM) are two useful analytical tools in diverse research areas. Recently, fluorescent nanodiamonds (FNDs) have emerged as promising imaging agents for both CL and CLEM owing to their exceptional photophysical and chemical properties. However, to realize their practical applications in the life sciences, surface modification and functionalization of the nanomaterials with bioactive molecules are critical and essential. Here we provide a comprehensive review on the methods of synthesizing biohybrid FNDs as well as recent advances of CL and CLEM imaging of cells with these carbon nanoparticles as dual‐contrast markers.