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Facile synthesis of multi‐functional 1,3,4‐thiadiazine derivatives bearing phthalazine, pyridazine, and pyrido‐pyridazine moieties
Author(s) -
Gudala Satish,
Ambati Srinivasa Rao,
Sharma Archi,
Patel Jeevan Lal,
Vedula Rajeswar Rao,
Penta Santhosh
Publication year - 2019
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800093
Subject(s) - chemistry , phthalazine , pyridazine , acetic acid , ethanol , benzene , combinatorial chemistry , sulfonamide , organic chemistry , substrate (aquarium) , medicinal chemistry , geology , oceanography
A series of novel, multifunctional 1,3,4‐thiadiazine derivatives bearing phthalazines, pyridazines and pyrido‐pyridazines ( 9–13 ) have been synthesized via the multicomponent reaction of (3‐(2‐bromo‐2‐[2‐chloropyrimidin‐4‐yl]acetyl)‐2‐chlorophenyl)‐2,6‐dichloro benzene‐sulfonamide with thiocarbohydrazide and various anhydrides. The reactions were performed by refluxing the components in mixed ethanol/acetic acid to afford the corresponding products in good to excellent yields. All the synthesized compounds were characterized by analytical and spectral studies. The developed method features short reaction time, simple work‐up without chromatographic separation, and a broad range of substrate applicability.