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Green synthesis of novel pyrazolo‐fused benzophenazines using H 3 PW 12 O 40 as efficient and recyclable catalyst under microwave irradiation
Author(s) -
Mohebat Razieh,
Dehgan Parisa,
YazdaniElahAbadi Afshin
Publication year - 2018
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800071
Subject(s) - chemistry , catalysis , phosphotungstic acid , atom economy , reagent , yield (engineering) , green chemistry , condensation , microwave irradiation , reusability , microwave , nuclear chemistry , combinatorial chemistry , organic chemistry , reaction mechanism , thermodynamics , programming language , quantum mechanics , physics , computer science , materials science , software , metallurgy
A high‐yield, atom‐efficient, and green protocol for the synthesis of novel pyrazolo‐fused benzophenazines utilizing a multicomponent condensation reaction between 2‐hydroxynaphthalene‐1,4‐dione, o ‐phenylenediamine, aromatic aldehydes, and 4‐methylbenzenesulfonohydrazide in the presence of phosphotungstic acid (H 3 PW 12 O 40 ) under microwave irradiation (MWI) in EtOH is reported. We provide a novel series of 1 H ‐benzo[ a ]pyrazolo[3,4‐ c ]phenazine derivatives interesting for biological screening tests. This protocol offers several advantages satisfying many principles of green chemistry, including atom economy, energy saving, clean reactions, inexpensive reagents, reusability of H 3 PW 12 O 40 , the absence of any tedious work‐up or purification, and avoidance of hazardous or toxic reagents/catalysts/solvents.