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Citrate trisulfonic acid: A heterogeneous organocatalyst for the synthesis of highly substituted Imidazoles
Author(s) -
Kanaani Elham,
NasrEsfahani Masoud
Publication year - 2019
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201800015
Subject(s) - chemistry , benzoin , ammonium acetate , trisodium citrate , catalysis , aniline , combinatorial chemistry , organic chemistry , high performance liquid chromatography , nuclear chemistry
Citrate trisulfonic acid (CTSA), as a novel recyclable and eco‐benign organocatalyst, was employed for the efficient and one‐pot synthesis of trisubstituted imidazoles and tetrasubstituted imidazoles using aldehydes, ammonium acetate or aniline, and benzoin, benzyl, or 9,10‐phenanthrenequinone under solvent‐free conditions providing high to excellent yields. CTSA is easily prepared via the reaction of trisodium citrate and chlorosulfonic acid in high purity. Compared to the conventional procedures, the present method offers several advantages, including high yields, easy work‐up, short reaction time, reusability of the catalyst, and simple purification of the products.