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A green and practical one‐pot two‐step strategy for the synthesis of symmetric 3,6‐diarylpyridazines
Author(s) -
Rimaz Mehdi,
Mousavi Hossein,
Khalili Behzad,
Aali Farkhondeh
Publication year - 2018
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201700470
Subject(s) - chemistry , hydrazine (antidepressant) , atom economy , hydrate , aryl , catalysis , simple (philosophy) , combinatorial chemistry , salient , column chromatography , organic chemistry , chromatography , artificial intelligence , alkyl , epistemology , philosophy , computer science
A simple, mild, and efficient synthesis of symmetric 3,6‐diarylpyridazine derivatives using a green catalytic one‐pot two‐step reaction of aryl methyl ketones, arylglyoxal monohydrates, and hydrazine hydrate was developed. Environmentally benign nature, high atom‐economy, no harmful byproduct, easy workup procedure, no column chromatography steps, and moderate to excellent yields of the products are the salient features of this new multicomponent‐based methodology.