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Progress in Total Syntheses of Anti‐malignant Pleural Mesothelioma Compounds
Author(s) -
Man Yi,
Liu Bo
Publication year - 2018
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201700360
Subject(s) - chemistry , mesothelioma , furan , cytotoxic t cell , cancer research , stereochemistry , organic chemistry , biochemistry , pathology , in vitro , medicine
Malignant pleural mesothelioma (MPM) is a fatal tumor, which spreads aggressively and highly resists conventional chemotherapeutic agents. It continues to be a difficult clinical problem, and efficient treatment is still an enormous challenge. Alimta is used currently as an anti‐MPM medicine, obtained mainly through chemical syntheses. Meanwhile, phenanthroindolizidine alkaloids such as tylophorine and cuevaene A, diterpenes such as cafestol and kahweol, naphthoquinones such as JBIR‐76 and JBIR‐77, anagucycline C‐glycosides, and dodecahydrodibenzo[ b,d ]furan skeletons such as JBIR‐23 and JBIR‐24 have been isolated and found with different cytotoxic effects against several MPM cell lines. The present short review summarizes the synthetic strategies of these anti‐MPM molecules.