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Carbonylative Sonogashira Coupling of Aryl Iodides with Terminal Alkynes Catalyzed by Palladium Nanoparticles
Author(s) -
Feng Xiujuan,
Song Jiliang,
Bao Ming
Publication year - 2018
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201700302
Subject(s) - sonogashira coupling , chemistry , aryl , palladium , catalysis , carbon monoxide , carbonylation , combinatorial chemistry , nanoparticle , coupling reaction , organic chemistry , nanotechnology , alkyl , materials science
A convenient and efficient method for the synthesis of α,β‐alkynyl ketones from the three‐component coupling of aryl iodides, terminal alkynes, and carbon monoxide (carbonylative Sonogashira coupling reaction) is successfully developed. The carbonylative Sonogashira coupling reaction proceeded smoothly under mild conditions in the presence of palladium nanoparticles to produce the corresponding α,β‐alkynyl ketones in good to excellent yields.