A Green Approach for the One‐Pot, Three‐Component Synthesis of 2‐Arylpyrroloacridin‐1(2 H )‐Ones using Lactic Acid as a Bio‐based Catalyst under Solvent‐Free Conditions | Zendy

Fatahpour Maryam | Zendy; Hazeri Nourallah | Zendy; Maghsoodlou Malek Taher | Zendy; Lashkari Mojtaba | Zendy

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A Green Approach for the One‐Pot, Three‐Component Synthesis of 2‐Arylpyrroloacridin‐1(2 H )‐Ones using Lactic Acid as a Bio‐based Catalyst under Solvent‐Free Conditions

Author(s) -

Fatahpour Maryam,

Hazeri Nourallah,

Maghsoodlou Malek Taher,

Lashkari Mojtaba

Publication year - 2017

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.201700128

Subject(s) - chemistry , dimedone , reusability , lactic acid , catalysis , organic chemistry , column chromatography , green chemistry , solvent , component (thermodynamics) , combinatorial chemistry , reaction mechanism , bacteria , physics , thermodynamics , software , biology , computer science , genetics , programming language

A facile and benign synthetic strategy is proposed for the synthesis of 2‐arylpyrroloacridin‐1(2 H )‐ones via a lactic acid‐catalyzed three‐component reaction of dimedone, various anilines, and isatins under solvent‐free conditions. Avoidance of hazardous organic solvents, the use of a one‐pot multicomponent procedure for the synthesis of 2‐arylpyrroloacridin‐1(2 H )‐ones, operational simplicity, no need for column chromatography, lactic acid utilization as a bio‐based organic compound, reusability, homogeneity, and commercial availability of the catalyst, and superior synthetic performance are some important aspects of this methodology to access a series of pyrroloacridine motifs with potentially biological scaffolds.

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