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A Green Approach for the One‐Pot, Three‐Component Synthesis of 2‐Arylpyrroloacridin‐1(2 H )‐Ones using Lactic Acid as a Bio‐based Catalyst under Solvent‐Free Conditions
Author(s) -
Fatahpour Maryam,
Hazeri Nourallah,
Maghsoodlou Malek Taher,
Lashkari Mojtaba
Publication year - 2017
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201700128
Subject(s) - chemistry , dimedone , reusability , lactic acid , catalysis , organic chemistry , column chromatography , green chemistry , solvent , component (thermodynamics) , combinatorial chemistry , reaction mechanism , bacteria , physics , thermodynamics , software , biology , computer science , genetics , programming language
A facile and benign synthetic strategy is proposed for the synthesis of 2‐arylpyrroloacridin‐1(2 H )‐ones via a lactic acid‐catalyzed three‐component reaction of dimedone, various anilines, and isatins under solvent‐free conditions. Avoidance of hazardous organic solvents, the use of a one‐pot multicomponent procedure for the synthesis of 2‐arylpyrroloacridin‐1(2 H )‐ones, operational simplicity, no need for column chromatography, lactic acid utilization as a bio‐based organic compound, reusability, homogeneity, and commercial availability of the catalyst, and superior synthetic performance are some important aspects of this methodology to access a series of pyrroloacridine motifs with potentially biological scaffolds.