Premium
Cu (I) ‐catalyzed Green Synthesis of Propargyl Amines Decorated with Carbazole Moiety by A 3 ‐Coupling
Author(s) -
Shehzadi Syeda Aaliya,
Saeed Aamer
Publication year - 2017
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201700061
Subject(s) - chemistry , carbazole , propargyl , moiety , catalysis , solvent , medicinal chemistry , organic chemistry , polymer chemistry
A series of novel N ‐alkylcarbazol–propargylamine hybrids were designed and synthesized by Cu I Br ‐catalyzed A 3 ‐coupling of N ‐octylcarbazol‐3‐carbaldehyde, amines, and alkynes. The tri‐substituted propargyl amines decorated with carbazole moiety were obtained under solvent‐free conditions in good to moderate yields. Furthermore, the scope of the method was studied, which was found to be applicable to primary aliphatic and aromatic amines. Also, a large variety of substituents both on alkynes and anilines are well tolerated.