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Cover Picture: Journal of the Chinese Chemical Society 8/2016
Publication year - 2016
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201680801
Subject(s) - chemistry , citation , cover (algebra) , guanine , library science , cancer research , cytotoxicity , computer science , biochemistry , medicine , mechanical engineering , nucleotide , engineering , gene , in vitro
Many antitumor alkylating agents exert their cytotoxicity by targeting the O 6 ‐position of guanine to cause DNA damage. However, the therapeutic effects of the drugs can be significantly attenuated by O 6 ‐methylguanine‐methyltransferase (MGMT), which repairs the O 6 ‐alkylguanine lesions. In this paper, we describe a MGMT‐activated fluorescence turn‐on probe for the rapid no‐wash imaging of MGMT in living cells. We believed that the probe can be used as a prognostic indicator for tumor resistance to antitumor alkylating agents to provide a guide for therapeutic decisions. More details about this figure will be discussed on page 688–693 in this issue.