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Synthesis of Hydrazones from Amino Acids and their Antimicrobial and Cytotoxic Activities
Author(s) -
Abid ObaidurRahman,
Khatoon Ghamama,
Arfan Muhammad,
Sajid Imran,
Langer Peter,
Rehman Wajid,
Rahim Fazal,
Yasir Muhammad,
Waqar Muhammad,
Haleem Kashif Syed
Publication year - 2017
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201600859
Subject(s) - chemistry , antimicrobial , cytotoxicity , methanol , amino acid , ethanol , organic chemistry , elemental analysis , combinatorial chemistry , biochemistry , in vitro
Hydrazones 6a–6n were synthesized from different amino acids with various aldehydes under reflux in methanol/ethanol. The structures of synthesized compounds were ascertained by elemental analysis and spectroscopic techniques. A comparative study of the antimicrobial activity and cytotoxicity was carried out of the N‐protected amino acids, their esters, hydrazides, and the respective hydrazones, providing good results in cytotoxicity studies.