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Insight into the Reaction Mechanism of α‐Amino Phosphonate Synthesis Using Succinic Acid as a Catalyst: Computational Kinetic Approach
Author(s) -
HabibiKhorassani Sayyed Mostafa,
Shahraki Mehdi,
Yaghoubian Halimeh
Publication year - 2017
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201600765
Subject(s) - chemistry , reactivity (psychology) , aniline , benzaldehyde , reaction mechanism , catalysis , polar effect , phosphonate , imine , medicinal chemistry , photochemistry , computational chemistry , organic chemistry , medicine , alternative medicine , pathology
The reaction mechanism in the synthesis of particular α‐amino phosphonates from 4‐methyl benzaldehyde, aniline, and trimethyl phosphite in the presence of succinic acid is theoretically investigated. The profile of the potential energy surface is constructed at both HF /6‐31 + G(d,p) and B3LYP /6‐31 + G(d,p) levels of theory for evaluating all the steps involved in the reaction mechanism. In order to investigate the effect of the structure on reactivity, some para ‐substituted benzaldehydes are subjected to kinetic examination. The overall reaction in the presence of electron‐withdrawing groups is thermodynamically much more favorable than in the presence of the electron‐donating groups; similarly, the reaction is kinetically more favorable and much easier in the presence of electron‐withdrawing groups. Moreover, step 2 (imine formation) is recognized as the rate‐determining step at both levels of theory. Also, step 1 is diffusion‐controlled with both electron‐withdrawing and electron‐donating groups, while the other steps are chemically controlled in the reaction mechanism.

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