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13 C‐Isotope Labeled Surrogate for Estimating Organophosphorus Pesticides in Agricultural Products by Gas Chromatography‐Mass Spectrometry
Author(s) -
Chen YanFu,
Kao ChangLong,
Lee WeiKun,
Huang PingChih,
Hsu ChingYun,
Kuei ChunHsiung
Publication year - 2016
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201600115
Subject(s) - chemistry , mass spectrometry , chromatography , paraoxon , gas chromatography , isotope , pesticide , gas chromatography–mass spectrometry , deuterium , isotope dilution , organic chemistry , physics , quantum mechanics , agronomy , acetylcholinesterase , biology , enzyme
13 C‐isotope labeled paraoxon‐ethyl ( 13 C 2 ‐EP) and deuterium‐labeled paraoxon‐methyl (D 6 ‐MP) were synthesized and employed as the surrogate (SS) and the internal standard (IS) in organophosphorus pesticides (OPs) spiking agricultural QC samples. The residual amounts of OPs were determined with gas chromatography‐mass spectrometry (GC‐MS) method. The isotope‐labeled compounds used in this study could assist the analysts to estimate the appropriateness and the uncertainties produced by pre‐treatment process. It was found that these isotope labeled compounds could improve the accuracy (10% to 40% of quantitative analysis), and provide efficacious calibration for the spiking recoveries of OPs in some agricultural samples.