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Antimicrobial Treatment of Different Metal Oxide Nanoparticles: A Critical Review
Author(s) -
Parham Shokoh,
Wicaksono Dedy H. B.,
Bagherbaigi Saeedeh,
Lee Siew Ling,
Nur Hadi
Publication year - 2016
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201500446
Subject(s) - antimicrobial , chemistry , reactive oxygen species , metal , nanoparticle , oxide , oxidative stress , nanomaterials , cytotoxicity , combinatorial chemistry , nanotechnology , organic chemistry , biochemistry , materials science , in vitro
Many nanomaterials can be used as metal oxides (Ti, Ag, Zn, Cu, Mg, Ca, Ce, Yt, Al). Metal oxide nanoparticles have strong antimicrobial properties. The oxides that play a large role as antimicrobial agents can be divided into two major groups based on their mechanism of action i.e., those that involve oxidation and those that inhibit the production of Reactive Oxygen Species (ROS). Previous studies have shown that, toxic metals like silver and titanium, and their metals oxides, employ the ROS‐mediated mechanism that leads to oxidative stress‐related cytotoxicity, cancer, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound heal‐ ing. Other metal oxide nanoparticles, like Y 2 O 3 , CeO 2 and Al 2 O 3 act as free radical scavengers. Out of these, aluminium oxide nanoparticles are more effective antimicrobial agents, than the other metal oxide nanoparticles. A combination of Al 2 O 3 and other antimicrobial agents such as TiO 2 may act as ideal antimicrobial agents, along with possessing free radical scavenging activity. This critical review aims to study the antimicrobial properties of different metal oxide nanoparticles and the mechanism of action in‐ volved, besides comparing their efficacy to eliminate bacteria.