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Synthesis, Spectroscopy, Semi‐empirical and Biological Activities of Organotin(IV) Complexes with o ‐Isopropyl Carbonodithioic Acid
Author(s) -
Javed Fatima,
Ali Saqib,
Shahzadi Saira,
Khalid Nasir,
Tabassum Saira,
Khan Imran,
Sharma Saroj K.,
Qanungo Kushal
Publication year - 2015
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201500235
Subject(s) - chemistry , isopropyl , denticity , spectroscopy , infrared spectroscopy , nuclear magnetic resonance spectroscopy , stereochemistry , ligand (biochemistry) , biological activity , crystallography , complex formation , binding constant , potassium , proton nmr , stability constants of complexes , medicinal chemistry , ultraviolet visible spectroscopy , inorganic chemistry , binding site , aqueous solution , organic chemistry , crystal structure , in vitro , biochemistry , receptor , physics , quantum mechanics
New organotin(IV) complexes have been synthesized by treating potassium o ‐isopropyl carbonodithioate with R 2 SnCl 2 /R 3 SnCl in 1 : 2/1 : 1 M/L ratio. All complexes have been characterized by IR and NMR ( 1 H, 13 C) spectroscopy. IR results shows that ligand acts as bidentate which is also confirmed by semi‐empirical study. NMR data reveals four coordinated geometry in solution. Computed positive heat of formation shows that complex 5 is thermodynamically unstable. UV/visible spectroscopy was used to assess the mode of interaction and binding of the complexes with DNA which shows that complex 5 exhibits higher binding constant as compared to complex 3 . In protein kinase inhibition assay, compound 3 was found most active, while other biological activities shows that triorganotin(IV) complexes are biologically more active as compared to diorganotin(IV) complexes.