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Chemical Constituents from Alafia Barteri Oliv. Leaves with Cytotoxic Activity
Author(s) -
Aiyelaagbe Olapeju O.,
Negi Arvind S.,
Hamid Abdulmumeen A.,
Luqman Suaib,
Kumar Sathish B.,
Kaneez Fatima
Publication year - 2015
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201500213
Subject(s) - chemistry , stigmasterol , cytotoxic t cell , cytotoxicity , cancer cell lines , triterpenoid , stereochemistry , methanol , traditional medicine , cancer cell , organic chemistry , biochemistry , chromatography , cancer , in vitro , medicine
Methanol extract of Alafia barteri leaves showed cytotoxic activity on leukaemia carcinoma K562, and hepatic liver cancer cells WRL (IC 50 values 193.1 and 225.0 μM respectively). Isolation of the extract gave ursane triterpenoid, 28‐acety‐urs‐5,20‐dien‐2β,3β,24α‐triol, 1 , together with undecanol, 2 , stigmasterol, 3 and octadecanoic acid, 4 . The structures of these compounds were identified by spectroscopic analysis, including MS, 1D and 2D NMR, and supported with literature data. Compound 1 exhibited cytotoxic activity against K‐562 at 50 and 100 μM concentrations with IC 50 74.22 μM, while compounds 2 , 3 and 4 showed low inhibition of WRL, MCF‐7 and COLO cell lines.