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Synthesis, Chemical Characterization, DNA Interaction and Antioxidant, Studies of New Nitrosubstituted Thioureas and Their Copper Complexes
Author(s) -
Patujo Jahangeer,
Badshah Amin,
Hussain Raja Azadar,
Tahir Muhammad Nawaz,
Tahir Shaista,
Rauf Muhammad Khawar
Publication year - 2015
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201500169
Subject(s) - chemistry , thiourea , copper , fourier transform infrared spectroscopy , nuclear chemistry , nitro , medicinal chemistry , organic chemistry , polymer chemistry , alkyl , physics , quantum mechanics
In the present work new nitro substituted thioureas, and their copper complexes have been synthesized and characterized by FTIR and multinuclear NMR techniques. Some of the compounds namely 1‐benzoyl‐3‐(4‐chloro‐3‐nitrophenyl) thiourea (A‐1), 1‐benzoyl‐3‐(4‐chloro‐3‐nitrophenyl) thiourea (A‐2) and 1‐benzoyl‐3‐(2‐methoxy‐4‐nitrophenyl) thiourea (A‐2) have also been characterized by single crystal XRD. All the synthesized compounds have been screened for DNA binding potencies (using cyclic voltametry, UV‐vis spectroscopy) and free radical scavanging activities.