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Voltammetric Determination of Sophoridine Based on Gold Nanoparticles/L‐cysteine/ Graphene Modified Glassy Carbon Electrode
Author(s) -
Wang Fei,
Zhao Longtao,
Yang Liu,
Li Bei,
Qiang Liming,
Gao Lin
Publication year - 2015
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201400527
Subject(s) - graphene , overpotential , chemistry , detection limit , electrode , electrochemistry , oxide , colloidal gold , glassy carbon , electrochemical gas sensor , analytical chemistry (journal) , nanoparticle , inorganic chemistry , nanotechnology , cyclic voltammetry , chromatography , materials science , organic chemistry
A new strategy to make the electrochemical sensor was presented, through combining gold nanoparticles (GNPs) with reduced graphene oxide (rGO) via L‐cysteine (L‐cys) as crosslinker. The resulting electrodes were characterized by scanning electron microscopy (SEM) and electrochemical methods. And it was applied to develop a high‐sensitive electrochemical sensor for determination of sophoridine. Compared with the bare GCE and reduced graphene oxide modified electrode, the resulting electrodes exhibited excellent response toward the oxidation of sophoridine by significantly enhancing the oxidation peak currents and decreasing the overpotential of sophoridine. Under the selected conditions, there exist the linear relation between the oxidation peak currents and sophoridine concentration in the range of 1.0 x 10 ‐6 ∼1.0 x 10 ‐4 mol L ‐1 , with detection limit of 4.0 x 10 ‐7 mol L ‐1 . At the same time, the method can be successfully applied to the quantitative determination of sophoridine in injection samples and its result is satisfactory.