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Simultaneous Determination of Six Compounds in Wen‐Pi‐Tang‐Hab‐Wu‐Ling‐San Using an HPLC‐DAD Method and Application in a Pharmacokinetic Study
Author(s) -
Chen Jianbo,
Kim Youngho,
Park Yongki,
Byun Youngjoo,
Kang Jongseong
Publication year - 2015
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201400488
Subject(s) - chemistry , pharmacokinetics , chromatography , high performance liquid chromatography , pi , plasma concentration , pharmacology , biochemistry , medicine
An HPLC‐DAD‐method was established for simultaneous determination of 6 main active components in WHW. The method was validated for specificity, accuracy, precision. The developed method was successfully applied to the pharmacokinetics of salvianolic acid B in rat plasma after administration of WHW, Salviae Miltiorrhizae and pure salvianolic acid B. Statistically significant differences in pk parameters of salvianolic acid B.