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A Modified and Practical Synthetic Route to Indazoles and Pyrazoles Using Tungstate Sulfuric Acid
Author(s) -
Rahmatzadeh S. Setareh,
Karami Bahador,
Khodabakhshi Saeed
Publication year - 2015
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201400251
Subject(s) - chemistry , indazole , tungstate , sulfuric acid , pyrazole , catalysis , hydrazine (antidepressant) , atom economy , condensation , solvent , condensation reaction , organic chemistry , combinatorial chemistry , chromatography , physics , thermodynamics
Tungstate sulfuric acid‐catalyzed Knorr reaction have been used as a simple, rapid, atom economic and green method for the synthesis of indazole and pyrazole derivatives based on the condensation of hydrazine derivatives and ß ‐dicarbonyl compounds under solvent‐free conditions. It was found that the catalyst could be recovered and reused without significant loss of its activity. The use of this method provides a novel and improved modification of Knorr synthesis in terms of clean reaction profile, use of a safe catalyst and solvent‐free conditions.