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Regioselective One‐pot Synthesis of New Unsymmetric Spiro Dihydrofurans in the Reaction of Mixed Two Different Cyclic β‐Dicarbonyl Compounds with BrCN and Aldehydes in the Presence of Et 3 N
Author(s) -
Noroozi Pesyan Nader,
Shokr Alireza,
Gharib Ali,
Tunç Tuncay,
Sahin Ertan
Publication year - 2015
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201400224
Subject(s) - chemistry , triethylamine , regioselectivity , bromide , nuclear magnetic resonance spectroscopy , medicinal chemistry , organic chemistry , catalysis
Crossed one‐pot reaction of mixed cyclic β‐dicarbonyl with various aldehydes in the presence of cyano gen bromide and triethylamine leads to the selective and efficient formation of crossed new unsymmetri cal spiro dihydrofurans at room temperature. The products were obtained in good to excellent yields. Structure elucidation was carried out by 1 H NMR, 13 C NMR, FT‐IR spectroscopy, Mass analyses and X‐ray crystallography technique. A proposed mechanism was discussed for the formation of products.